Structural modifications that alter the P-glycoprotein efflux properties of compounds

J Med Chem. 2012 Jun 14;55(11):4877-95. doi: 10.1021/jm201136z. Epub 2012 Apr 16.

Author

Stephen A Hitchcock¹

Affiliation

¹ Envoy Therapeutics, 555 Heritage Drive, Jupiter Florida 33458, United States. stephen.hitchcock@envoytherapeutics.com

PMID: 22506484
DOI: 10.1021/jm201136z

No abstract available

Publication types

Review

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
Animals
Blood-Brain Barrier / metabolism
Cell Line
Central Nervous System Agents / chemistry*
Central Nervous System Agents / pharmacokinetics
Central Nervous System Agents / pharmacology
Central Nervous System Agents / therapeutic use
Central Nervous System Diseases / drug therapy*
Central Nervous System Diseases / metabolism
Drug Design*
Humans
Models, Molecular
Permeability
Structure-Activity Relationship

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Central Nervous System Agents